No studies excluded eligible patients or used variable follow-up Risk of bias due to confounding, 5, 6, 9, 26, 29, 33 as there were adequate prognostic variables that predicted baseline The 6 nonrandomized studies are presented in Figure 2. The results of the methodological quality assessment (using the ROBINS-I tool) of Outcome data, selection of outcomes reported, and other sources of bias. 25 Risk of bias for 1 randomized study 24 was assessed according to the Cochrane risk of bias tool, 15 which incorporates an assessment of randomization, blinding, completeness of A score of <0.20 indicated poor agreement Ġ.21-0.40, fair agreement 0.41-0.60, moderate agreement 0.61-0.80, good agreement Īnd 0.81-1.00, very good agreement. 5, 6, 9, 26, 29, 33 A Cohen kappa score was calculated to determine the level of intraobserverĪgreement between reviewers. Selection of outcomes reported, and other sources of bias. Participants, deviations from intended interventions, completeness of outcome data, Risk of bias was assessed for 6 studies according to the Risk ofīias in Nonrandomized Studies of Interventions (ROBINS-I) tool, 34 which incorporates an assessment of bias based on confounding, selection of There was no need for funding or a third party to obtain any of theĬollected data. Exclusion criteria included nonhuman studies and studiesĭata extraction from each study was performed independently and reviewed by a secondĪuthor (J.W.B.). HUC-MSCs for knee OA, studies that were published in English, and studies with a The inclusion criteria were human studies that assessed the use of In cases of disagreement, a third reviewer (A.J.S.) made the finalĭecision. Reviewed by title and/or abstract to determine study eligibility based on inclusionĬriteria. The Cochrane Library up to January 20, 2021. Two independent reviewers (J.W.B., M.J.K.) searched PubMed, Embase, and This systematic review was conducted according to PRISMA (Preferred Reporting Itemsįor Systematic Reviews and Meta-Analyses) guidelines and followed a PRISMAĬhecklist. Hypothesized that hUC-MSC treatment would significantly improve pain relief. The purpose of this study was to perform a systematic review of the literature toĮvaluate the efficacy of hUC-MSCs in the treatment of OA of the knee joint. Umbilical cord, hUC-MSCs offer the advantages of greater proliferative capacity withoutīeing subjected to ethical controversy in the same way as human embryonic stem cells. MSCs studied in the treatment of knee OA. The treatment of knee OA, 12, 17 human umbilical cord–derived MSCs (hUC-MSCs) are a relatively novel source of 1, 28 Whereas bone marrow– and adipose-derived MSCs have been studied extensively for ![]() In clinical studies using MSCs, it is important to distinguish the harvest site, as theseĬells may exhibit differential characteristics regarding rates of proliferation andĬhondrogenic differentiation potential. 36 MSCs can be further differentiated as deriving from bone marrow, 11 adipose tissue, 38 synovial tissue, 20 and the umbilical cord, 24 among other harvest sites. Therapies may include platelet-rich plasma (PRP), 2 bone marrow aspirate concentrate, 18, 21, 30 and mesenchymal stem cells (MSCs). In patients with early osteoarthritis (OA) or focal chondral defects. ![]() Good luck.As the use of biologic therapies has received increasing interest in recent years in theįield of orthopaedics, clinicians are continuously finding new methods to treat symptoms Before you start: do a lot of online reading. It also can be done with bone marrow, which is as I understand it a bit more painful to extract, but the recovery is easier. Good doctors will not recommend stem cell therapy on patients if they think it has no chance to work. Then get x-rays and talk with the doctor to see what advice they have. There are tons of scams out there so be careful. Probably your first step is to locate a reputable doctor in your area. I could have tried again with stem calls, but the cost adds up, plus the uncertainty. ![]() The reason I had to have a total knee replacement is because last Feb (2019) I fell down hard on my knee tripping over a jut in the sidewalk in the dark. It cost total around $8,000 (one knee) and was not covered by insurance. You should check out local practitioners and talk with them – I don't think they can guarantee success. ![]() But the problem is that you never know if it will be successful or not. It was quite successful for me it did not eliminate all the pain, but pain was minor. The process for me was PRP (plasma rich platelets, derived from your blood), injected then the stem cells, then another PRP. There is a big difference in the stem cell therapy I had, and the stem cell transplant (from human embryonic cells) that people with serious illnesses get. I had stem cell (not transplants – from my own fat cells) done on my knee a few years ago.
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